P-207
846-2727
Additional Notes|Case Studies|Exam (Samples)|Home|Homework|Links|Problem Sets|Schedule|Simulations|Support|COP|
PHA 5127
Basic Principles of Dose Optimization
2 Credits
Fall 1999
Instructor:
Dr. Guenther Hochhaus
P-207
846-2727
Graduate Student Teaching Assistants: |
Jeffrey Stark - P209: 846-2730 Qun (Tracey) Wei P304 392-3412 |
| Competencies |
|
| Equations Sheets: Useful pk equations  Equations for one compartment body model |
Grading System |
| Objectives | Office Hours |
| Lecture Schedule Fall 1999 | Links to various relevant websites |
| Required Reading | |
| Sample Exam for Practice | Simulations On-Line and Excel files to download |
Goal: Understanding the importance of drug concentration/time relationships for optimal drug therapy.
Course Description:
An introduction to the study of the time course of drugs in the body with reference to their absorption, distribution metabolism, and elimination (ADME). Consideration is given to rate processes, the physiochemical influences on ADME, and formulation factors involved in drug delivery and availability.
| Lectures: | Wed.. 5th period(11:45-12:35) C1-9 |
| Friday 5th period(11:45-12:35) C1-9 |
Office Hours: Friday 12:50-1:40pm, or whenever instructor has time
Exams: There will be 2 written exams and 6 homework assignments. The homework assignments will be given on the Case Studies Days, due the next lecture, and will be worth 5 points each.
| Date | Maximum Points | % Total | |
| 1st Exam | Oct. 15, 1999 | 160 | 40 |
| Final Exam | Dec. 14, 1999 10:30-12:30 Room TBA |
200 | 50 |
| Homework/Case Studies | 40 | 10 | |
| TOTAL | 400 | 100 |
A key to the exam will be posted when exams are returned to students, and will remain posted for one week
Academic Honesty Guidelines:
Academic honesty guidelines are outlined in the University of Florida Student Guide and in the College of Pharmacy Student/Faculty Handbook. These guidelines will be strictly adhered.
Required Reading: Health Center Bookstore: Joseph T. DiPiro, Robert A. Blouin, Jane M. Pruemer, William J. Spruill, Concepts in Clinical Pharmacokinetics, 2nd EditionAmerican Society of Hosptial Pharmacists, Bethesda, 1996
Recommended Reading:
| Milo Gibaldi | Biopharmaceutics and Clinical Pharmacokinetics, 4th ed. Lea & Febiger, Philadelphia 1991 |
| Malcolm Rowland &Thomas N. Tozer | Clinical Pharmacokinetics Concepts and Applications 3rd ed. Lea & Febiger Philadelphia, 1995 |
| Michael E. Winter | Basic Clinical Pharmacokinetics 3rd Ed.Applied Therapeutics, Inc., Vancouver, WA |
Related sites and Resources
| 1. A First Course in Pharmaceutics and Biopharmaceutics | http://157.142.72.143/gaps/pkbio/pkbio.html (a very good course on the WORLD WIDE WEB) try it. |
| 2. Interactive Pharmacokinetic Teaching Module on Multiple Dosing by Mohsen A. Hedaya, College of Pharmacy, Washington State University. | http://barbital.phar.wsu.edu/hedaya/module01/ |
| 3. Pharmacokinetics: Pharmaceutics III by Mohsen A. Hedaya, College of Pharmacy, Washington State University. | http://virtual.phar.wsu.edu/phars433 |
| 4. Introductory Pharmacokinetic Workshop | CG68 Computer Lab |
| 5. Healthcare Education Learning & Information Exchange | http://www.helix.com |
| 6. Pharmacokinetics
Teaching Laboratory for Veterinary Students Virginia Maryland Regional College of Veterinary Medicine |
http://kineticlass.vetmed.vt.edu |
Calculators: Scientific calculators
Examinations: Mixture of multiple choice, essay questions and calculations. Questions concerning grading need to be asked not later than one week after grades were posted. The first exam will be given out. Final exams can be looked at, but will be kept.
Make-up Exams: Make-up exams will only be given, if important medical reasons exist (doctors excuse)
Grading: There will be no curving performed, unless the class average is significantly below a B grade.
Grades will be posted on the bulletin board (second floor)
It is the formal policy of this class that in order to fully and properly full the requirements of this course some use of and proficiency in the use of computers, including access to and use of the Internet (email and World Wide Web), will be required.
COURSE OBJECTIVES:
At the end of this course the student should be able to:
1. Understand the theoretical background of the pharmacokinetic behaviour of drugs.
2. Understand the influence of dosage forms, dosing regimens and dose on drug levels and to understand the relationship between drug concentration, effect and side effects.
3. Design optimized dosing regimens for patient care utilizing drug monitoring techniques and computer technology.
4. Apply the above principles for pharmacokinetic decision making and improvement of patient care.
STUDENT COMPETENCIES:
A. Recognize and resolve preventable drug-related problems.
B. Recognize and resolve ethical dilemmas in appropriate ways.
C. Design, implement, monitor, evaluate, document, and modify or recommend modifications in pharmacotherapy to insure effective, safe and economical pharmaceutical care.
D. Effectively communicate and educate both patients and other health care professionals in order to optimize pharmacotherapy and prevent future health problems.
E. Implement rational pharmacotherapy based on a mastery of biomedical (e.g. physiology, anatomy and immunology), pharmaceutical (e.g. pharmacology, toxicology, both pharmaceutical and medicinal chemistry, and pharmacy administration) and clinical (e.g. epidemiology, pathophysiology, pharmacokinetics and therapeutics) sciences.
F. Critically evaluate new advances in pharmacotherapy or systems of care and effectively utilize this new knowledge in patient care.