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PHA 5127

Basic Principles of Dose Optimization

2 Credits

Fall 2000

Instructor: Dr. Guenther Hochhaus

P-207
846-2727

Competencies	Exam Schedule Make-up exam
Equations Sheets: Useful pk equations Equations for one compartment body model	Grading System
Objectives	Office Hours
Lecture Schedule Fall 2000	Links to various relevant websites
	Required Reading
Sample Exam for Practice	Simulations On-Line and Excel files to download

Goal: Understanding the importance of drug concentration/time relationships for optimal drug therapy.

Course Description:

An introduction to the study of the time course of drugs in the body with reference to their absorption, distribution metabolism, and elimination (ADME). Consideration is given to rate processes, the physiochemical influences on ADME, and formulation factors involved in drug delivery and availability.

Office Hours: Friday 12:50-1:40pm, or whenever instructor has time

Exams: There will be 2 written exams and 6 homework assignments. The homework assignments will be given on the Case Studies Days, due the next lecture, and will be worth 5 points each.

A key to the exam will be posted when exams are returned to students, and will remain posted for one week

Academic Honesty Guidelines:

Academic honesty guidelines are outlined in the University of Florida Student Guide and in the College of Pharmacy Student/Faculty Handbook. These guidelines will be strictly adhered.

Required Reading: Health Center Bookstore: Joseph T. DiPiro, Robert A. Blouin, Jane M. Pruemer, William J. Spruill, Concepts in Clinical Pharmacokinetics, 2^nd EditionAmerican Society of Hosptial Pharmacists, Bethesda, 1996

Recommended Reading:

Related sites and Resources

Calculators: Scientific calculators

Examinations: Mixture of multiple choice, essay questions and calculations. Questions concerning grading need to be asked not later than one week after grades were posted. The first exam will be given out. Final exams can be looked at, but will be kept.

Make-up Exams: Make-up exams will only be given, if important medical reasons exist (doctors excuse)

Grading: There will be no curving performed, unless the class average is significantly below a B grade.

Grades will be posted on the bulletin board (second floor)

It is the formal policy of this class that in order to fully and properly full the requirements of this course some use of and proficiency in the use of computers, including access to and use of the Internet (email and World Wide Web), will be required.

COURSE OBJECTIVES:

At the end of this course the student should be able to:

1. Understand the theoretical background of the pharmacokinetic behaviour of drugs.

2. Understand the influence of dosage forms, dosing regimens and dose on drug levels and to understand the relationship between drug concentration, effect and side effects.

3. Design optimized dosing regimens for patient care utilizing drug monitoring techniques and computer technology.

4. Apply the above principles for pharmacokinetic decision making and improvement of patient care.

STUDENT COMPETENCIES:

A. Recognize and resolve preventable drug-related problems.

B. Recognize and resolve ethical dilemmas in appropriate ways.

C. Design, implement, monitor, evaluate, document, and modify or recommend modifications in pharmacotherapy to insure effective, safe and economical pharmaceutical care.

D. Effectively communicate and educate both patients and other health care professionals in order to optimize pharmacotherapy and prevent future health problems.

E. Implement rational pharmacotherapy based on a mastery of biomedical (e.g. physiology, anatomy and immunology), pharmaceutical (e.g. pharmacology, toxicology, both pharmaceutical and medicinal chemistry, and pharmacy administration) and clinical (e.g. epidemiology, pathophysiology, pharmacokinetics and therapeutics) sciences.

F. Critically evaluate new advances in pharmacotherapy or systems of care and effectively utilize this new knowledge in patient care.

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