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PHA 5127
Basic Principles of Dose Optimization
Lecture Schedule Fall 1999,
Wednesday 5th Period C1-9
Friday 5th Period C1-9
Input |
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| Aug. 25 | Introduction | 1-3 |
| Aug. 27 | Basic Pharmacokinetics (incl. first-order, zero order processes) | 4-6 |
| Sept. 1 | Volume of Distribution, Clearance, | 6,7 |
| Sept. 3 | Half-Life, Bioavailability | Sections of 9-13 |
| Sept. 8 | Case Study I
(online
answer) Homework
Set I |
|
| Sept. 10 | Systemic and Topical
Drug Administration-Biopharmaceutics |
28 |
| Sept. 15 | Gastrointestinal Absorption | |
| Sept. 17 | Parenteral
Absorption (pulmonary, nasal, transdermal, sublingual) Problem Set for Drug Absorption (with answers) |
|
| Sept. 22 | Parenteral Absorption (injections, implants) | |
| Sept. 24 | Protein Binding-
Tissue Distribution-Volume of Distribution Problem Set for Drug Distribution (with answers) |
32, 33,34 |
| Sept. 29 | Case Study II
Digoxin |
|
| Oct. 1 | Metabolism (High and Low Extraction Drugs, Intrinsic clearance) | 35,36, 37 |
| Oct. 6 | Metabolism
(Induction and Inhibition) Problem Set for Drug Metabolism (online answers) |
38 |
| Oct. 8 | Renal excretion-
Non-Renal Excretion Problem Set for Excretion |
40, 41 |
| Oct. 13 | Review 1 for Exam Answers for Review # 1 Questions |
|
| Oct. 15 | First Exam | |
| Oct. 20 | One Compartment Body
Model Problem Set for "One Compartment Model with i.v. Injection Only - Urinary Elimination |
9-13 |
| Oct. 22 | Single IV Bolus | 9-13 |
| Selected Computer
Simulations with Discussions |
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| Oct. 27 | Multiple IV Bolus Problem Set Multiple Dosing |
14, 15, 16, 17, 18, 19 |
| Oct. 29 | Case Study IV -
Aminoglycosides-gentamicin On-Line Answer Case Study on Warfarin Answer for printing Homework Set # 4 Answer Homework Set #4 |
|
| Nov. 3 | Single Oral Dose Problem Set Pharmacokinetics After Oral Administration |
28-31 |
| Nov. 5 | Homecoming No Classes |
|
| Nov. 10 | Multiple Oral Dose | 21,22,23 |
| Nov. 12 | IV Continuous Infusion | |
| Nov. 17 | Multiple IV Short
Term Infusion Homework # 5 |
24 |
| Nov. 19 | Case Study V-1999 |
|
| Nov. 24 | Two Compartment Body
Model Designing a Dosing Regimen - Problems |
25-27 |
| Nov. 26 | Thanksgiving Holiday No Class | |
| Dec. 1 | Three Compartment
Body Model Case Study # 6 |
|
| Dec. 3 | Nonlinear Pharmacokinetics | 39, 40 |
| Dec. 8 | Evaluation and Case Study VI | |
| Dec 14 | Final Exam 10:30am -12:30 pm Room TBA |
Last modified January 13, 2000