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PHA 5127

Basic Principles of Dose Optimization

Lecture Schedule Fall 1999,

Wednesday 5th Period C1-9

Friday 5th Period C1-9

Additional Help Pages

   

Input

Aug. 25 Introduction 1-3
Aug. 27 Basic Pharmacokinetics (incl. first-order, zero order processes) 4-6
     
Sept. 1 Volume of Distribution, Clearance, 6,7
Sept. 3 Half-Life, Bioavailability Sections of 9-13
     
Sept. 8 Case Study I (online answer)
Answer-pdf file

Homework Set I
Answer
Homework Set I (with answers)

 
Sept. 10 Systemic and Topical Drug Administration-Biopharmaceutics
Problem Set for Drug Administration (with answers)
28
     
Sept. 15 Gastrointestinal Absorption  
Sept. 17 Parenteral Absorption (pulmonary, nasal, transdermal, sublingual)
Problem Set for Drug Absorption (with answers)
 
     
Sept. 22 Parenteral Absorption (injections, implants)  
Sept. 24 Protein Binding- Tissue Distribution-Volume of Distribution
Problem Set for Drug Distribution (with answers)

Homework Set 2
32, 33,34
     
Sept. 29 Case Study II Digoxin
Answer by Jeffrey Stark

Case Study II (with answers)

 
Oct. 1 Metabolism (High and Low Extraction Drugs, Intrinsic clearance) 35,36, 37
     
Oct. 6 Metabolism (Induction and Inhibition)
Problem Set for Drug Metabolism (online answers)
38
Oct. 8 Renal excretion- Non-Renal Excretion
Problem Set for Excretion
40, 41
     
Oct. 13 Review 1 for Exam
Answers for Review # 1 Questions


Answer Homework # 3
file for printing

 
Oct. 15 First Exam  
     
Oct. 20 One Compartment Body Model
Problem Set for "One Compartment Model with i.v. Injection Only - Urinary Elimination
file for printing
9-13
Oct. 22 Single IV Bolus 9-13
  Selected Computer Simulations with Discussions
 
     
Oct. 27 Multiple IV Bolus
Problem Set Multiple Dosing

file for printing

14, 15, 16, 17, 18, 19
Oct. 29 Case Study IV - Aminoglycosides-gentamicin
On-Line Answer
file for printing answer (by Jeffrey Stark)
Case Study on Warfarin
Answer for printing
Homework Set # 4
Answer Homework Set #4
Answers for printing
 
     
Nov. 3 Single Oral Dose
Problem Set Pharmacokinetics After Oral Administration
Answers for printing
28-31
Nov. 5 Homecoming
No Classes
 
     
Nov. 10 Multiple Oral Dose 21,22,23
Nov. 12 IV Continuous Infusion  
     
Nov. 17 Multiple IV Short Term Infusion
Homework # 5
24
Nov. 19 Case Study V-1999
pdf file for printing
 
     
Nov. 24 Two Compartment Body Model
Designing a Dosing Regimen - Problems
25-27
Nov. 26 Thanksgiving Holiday No Class  
     
Dec. 1 Three Compartment Body Model
Case Study # 6
 
Dec. 3 Nonlinear Pharmacokinetics 39, 40
     
Dec. 8 Evaluation and Case Study VI  
Dec 14 Final Exam 10:30am -12:30 pm Room TBA  

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Last modified January 13, 2000