Basic Pharmacokinetics
Problems
1. Cocaine is known to follow one-compartment model pharmacokinetics. After 30mg is administered as a single i.v. bolus dose, the following data were observed.
Time (h) |
Conc (mg/L) |
1 |
0.0736 |
3 |
0.0100 |
Calculate its elimination rate constant and half-life.
2. A 30 year old, 55 kg woman, was given an i.v. bolus of ciprofloxacin (400 mg). Ciprofloxacin plasma concentrations are given in the following table. Given this information, determine the AUC from 0 to 10 hours using the trapezoidal method.
time (hr) |
Conc. (ng/ml) |
0 |
12.35 |
2 |
9.47 |
4 |
7.25 |
6 |
5.22 |
8 |
3.08 |
10 |
0.65 |