-
Brantly, M.L., Spencer, L.T., Humphries, M., Conlon, T.J., Spencer, C.T., Poirier, A., Song, S., Berns, K., Muzyczks, N Snyder R.O., Byrne, B.J., Flotte, T.R. (2006) Phase I Trial of Intramuscular Injection of a Recombinant Adeno-associated Virus Serotype 2 (rAAV2) Alpha-1 Antitrypsin (AAT) Vector in AAT-deficient Adults. Human Gene Therapy, 2006, 17(12):1177-1186.
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Lu, Y.**, Choi, Y-K.**, Campbell-Thompson, M., Li, C., Tang, Q., Crawford, J., Flotte, T. R. and Song, S.* (2006) Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector. Journal of Gene Medicine, 8:730-735.
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Lu, Y.**, Tang, M.**, Wasserfall, C., Kou, Z., Campbell-Thompson, M., Gardemann, T.**, Crawford, J., Atkinson, M., and Song, S.* (2006) 1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice. Human Gene Therapy, 2006, 17 (6):625-634.
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Zhang, B.**, Lu, Y.**, Campbell-Thompson, M., Spencer, T., Wasserfall, C., Atkinson, M., Song, S.* (2007) Alpha 1 antitrypsin protects beta-cells from apoptosis. Diabetes, 2007 56:1316-1323 .
- Petrache, I., Fijalkowska, I., Zhen, L., Medler1, T.R., Brown, E., Cruz, P., Choe, K-H., Taraseviciene-Stewart, L., Scerbavicius, R., Shapiro, L., Zhang, B.**, Song, S., Hicklin, D., Voelkel, N.F., Flotte, T., and Tudert, R.M. (2006) A novel anti-apoptotic role for alpha 1 antitrypsin in the prevention of emphysema. Am J Respir Crit Care Med. 2006 Mar 2; [Epub ahead of print] .
- Kwak, I., Song, S., Blum, J.L. Simmen, R.C.M. and Simmen, F.A. (2005) Enhancer- and Silencer-like Sequences that Mediate Insulin-Like Growth Factor-Binding Protein-2 Gene Expression in Uterine Cells of Pregnancy. DNA and Cell Biology 25(1):6-18.
- Burkhardt, B.R., Parker, M.J., Zhang, Y.C., Song, S., Wasserfall, C.H., Atkinson, M.A. (2005) Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice. FEBS Letters 579:5759-5764
- Conlon, T., Cossette, T., Erger, K., Choi, Y-K.**, Clarke, T., Scott-Jorgensen, M., Song, S., Campbell-Thomson, M., Crawford, J. and Flotte T. (2005) Efficient HepaticDelivery and expression from a recombinant adeno-associated virus 8 (rAAV8) pseudotyped alpha-1 antitrypsin vector.Molecular Therapy, 12 (5):867-875
- Virella-Lowell, I., Zusman, B., Forst, K., Loiler, S., Conlon, T., Song, S., Chesnut, K. A., Ferkol, T., Flotte, T. R. (2005) Enhancing rAAV vector expression in the lung. J Gene Med. 7:842-850
- Wei F-S, Song S, Zhao G, Lu Y, Li C-w, Wei J-F and Flotte TR, Stable transduction of murine embryonic stem cells with recombinant adeno-associated virus serotype 2 (rAAV2) vectors. Preclinica July/August.
- Song, S ., Witek, R.P., Lu, Y., Choi, Y-K., Zheng, D., Jorgensen, M., Li, C., Flotte, T.R. and Petersen, B.E., (2004) Ex Vivo tranduced liver progenitor cells as a platform for gene therapy in mice. Hepatology, 40(4): 918-924.
- Poirier, A., Campbell-Thompson, M, Tang, Q., Scott-Jorgensen, M., Combee,
L, Loiler, S., Crawford, J., Song, S., Flotte, T.R.. (2004) Toxicology
and Biodistribution Studies of a Recombinant Adeno-associated virus 2 (rAAV2)-Alpha-1
Antitrypsin (AAT) Vector. Preclinica, 2(1): 43-51.
- Song, S., K Goudy, M Campbell-Thompson, C Wasserfall, M Scott-Jorgensen,
J Wang, Q Tang, JM Crawford, TM Ellis, MA Atkinson, and TR Flotte. (2004)
Recombinant adeno-associated virus (rAAV2) mediated alpha-1 antitrypsin gene
therapy prevents type 1 diabetes in NOD mice.
Gene Therapy, 11: 181-186. (SS as corresponding author)
- Song, S., Lu, Y., Choi, Y., Han, Y-K., Tang, Q., Zhao, G., Berns,
KI and Flotte, T.R. (2004) DNA dependent Protein Kinase (DNA-PK) inhibits
adeno-associated virus (AAV) integration. ). Proc.
Natl. Acad. Sci. USA. 101(7): 2112-2116. (SS as corresponding author)
- Zhang, Y.C., Powers, M., Wasserfall, C., Brusko, T., Song, S., Flotte,
T.R., Snyder, R.O., Potter, M., Scott-Jorgensen, M., Campbell-Thompson, M.,
Crawford, J.M., Nick, H.S., Agarwal, A., Ellis, T.M., and Atkinson, M.A. (2004)
Immunity to adeno-associated virus serotype 2 delivered transgenes imparted
by genetic predisposition to autoimmunity. Gene
Therapy. 11:233-240.
- Loiler, S.A., Conlon, C.J., Song, S., Tang, Q., Warrington, K.H.,
Agarwal,A., Kapturczak, M., Li, C., Ricordi, C., Atkinson, M.A., Muzyczka,
N., Flotte, T.R. (2003) Targeting Recombinant Adeno-Associated Virus Vectors
to Enhance Gene Transfer. Gene
Therapy, 10:1551-1558.
- Goudy, K., Burkhardt, B., Wasserfall, C., Song, S., Campbell-Thompson,
M., Brusko, T., Powers, M., Clare-Salzler, M., Sobel, E., Ellis, T., Flotte,
T.R., and Atkinson, M.A. (2003) Systemic Over Expression of IL-10 Induces
CD4+ CD25+ Cell Populations In Vivo and Ameliorates Type 1 Diabetes in nonobese
diabetic Mice in a Dose-Dependent Fashion. Journal
of Immunology, 171:2270-2278.
- Song, S., Scott-Jorgensen, M., Wang, J., Poirier, A., Crawford, J.,
Camphell-Thompson, M., Flotte, T.R., (2002) Recombinant adeno-associated virus
2-alpha 1-antitrypsin (rAAV-AAT) vectors in a non-human primate model: safety
and immunologic aspects. Molecular
Therapy, 6(3):329-335.
- Mah, C., Fraites, T.J., Zolotukhin I., Song, S., Flotte, T.R., Batich,
C., Byrne B.J. (2002) Improved method of recombinant AAV2 delivery for systemic
targeted gene therapy. Molecular
Therapy, 6(1):106-112.
- Goudy, K., Song, S., Wasserfall, C., Zhang, Y.C., Kapturczak, M.,
Muir, A., Scott-Jorgensen, M., Campbell-Thompson, M., Crawford, J.M., Ellis,
T.M., Flotte, T.R., and Atkinson, M.A. (2001) Adeno-associated virus vector-mediated
IL-10 gene delivery prevents type 1 diabetes in NOD mice. Proc.
Natl. Acad. Sci. USA. 98(24):13913-13918. (GK and SS contributed equally).
- Song, S., Laipis, P.J., Berns, K.I., Flotte, T.R. (2001) Effect of
DNA-PKcs on the molecular fate of the rAAV2 genome in skeletal muscle. Proc.
Natl. Acad. Sci. USA. 98(7):4084-4088.
- Song, S., Embury, J. Laipis, P.J., Berns, K.I., Crawford J.M., Flotte,
T.R. (2001) Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT)after
portal vein injection of recombinant adeno-associated virus (rAAV) vectors.
Gene
Therapy, 8:1299-1306.
- Flotte, T.R., Agarwal, A., Wang, J., Song, S., Fenjves, E.S., Inverardi,
L., Chesnut, K., Fione, S., Loiler, S., Wasserfall, C., Kapturczak, M., Ellis,
T., Nick, H., Atkinson, M. (2001) Efficient ex vivo transduction of pancreatic
islet cell with recombinant adeno-associated virus vectors. Diabetes,
50:515-520.
- Xu, L., Daly, T., Gao, C., Byrne, B.J., Flotte, T.R., Song, S., Sands,
M.S., Ponder, K.P. (2001) The CMV- -actin promoter directed higher expression
from an AAV vector in the liver than the CMV or EF1 promoter and results in
therapeutic levels of human factor X in mice. Human
Gene Therapy, 12:563-573.
- Badinga, L., Song, S., Simmen, R.C.M., Clarke, J.B., Clemons, D.R.,
Simmen, F.A. (1999) Complex mediation of uterine endometrial epithelial cell
growth by insulin-like growth factor-II (IGF-II) and IGF-binding protein-2.
Journal
of Molecular Endocrinology, 23:277-285.
- Song, S., Morgan, M., Ellis, T., Poirier, A., Chesnut, K., Wang,
J., Brantly, M., Byrne, B.J., Atkinson, M., Muzyczka, N., Flotte, T.R. (1998)
Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced
with adeno-associated virus vectors. Proc.
Natl. Acad. Sci. USA. 95(24):14384-14388.
- Simmen, F.A., Badinga, L., Green, M.L., Kwak, I., Song, S. and Simmen,
R.C.M. (1998) The Porcine IGF System: At the Interface of Nutrition, Growth
and Reproduction. Journal
of Nutrition, 128:315s-320s.
- Badinga, L., Song, S., Simmen, R.C.M., Simmen, F.A. (1998) A distal
regulatory region of the insulin-like growth factor binding protein-2 (IGFBP-2)
gene interacts with the basic helix-loop-helix transcription factor, AP-4.
Endocrine,
8(3):281-289.
- Song, S., Lee, C.Y., Green, M.L., Chung, C.S., Simmen R.C.M., Simmen,
F.A. (1996) The unique endometrial expression and genomic organization of
the porcine IGFBP-2 Gene. Molecular
and Cellular Endocrinology, 120:193-202.
- Wang, C., Song, S., Bailey, L.B., Gregory, J. F. (1994) Relationship
between urinary excretion of p-aminobezoylglutamate and folate status of growing
rats. Nutrition Research, Vol. 14, pp. 875-884.