RESEARCH INTERESTS

• Pharmacokinetics and pharmacodynamics of corticosteroids
• Pharmacokinetics and pharmacodynamics of antibiotics
• Pharmacokinetics and pharmacodynamics of herbal drugs
• Microdialysis

• HPLC of drugs and metabolites in biological fluids
• Computer modeling for PK-PD analysis
• Somatosensory evoked potencies to measure analgesic effects
• Microdialysis to measure free tissue concentrations of drugs

• Pharmacokinetics
• Pharmacodynamics

1. Bhattaram V.A., Gräfe E.U., Kohlert C., Veit M., Derendorf H.  “Pharmacokinetics and Bioavailability of Herbal Medicinal Products.”  Phytomedicine 9(Suppl. III):1-36 (2002).
2. Meibohm B., Derendorf H.  “Pharmacokinetic/pharmacodynamic Studies in Drug Product Development.”  Journal of Pharm. Science, 91:18-31 (2002).
3. Derendorf H., Krishnaswami S., Hochhaus G., Möllmann H.  “Systemic Disposition and Effects of Inhaled Corticosteroids In ‘Airway Activity and Selectivity of Inhaled Steroids in Asthma’” ed. by Schleimer R., O’Byrne P., Szefler S., Brattsand R., Dekker, Lung Biology in Health and Disease, 163:247-272 (2001).
4. Derendorf H., Lesko L., Chaikin P., Colburn W.A., Lee P., Miller R., Powell R., Rhodes G., Stanski D., Venitz J.  “Pharmacokinetic/pharmacodynamic Modeling in Drug Research and Development.”  Journal of Clinical Pharmacology, 40:1399-1418 (2000).
5. de la Peña A., Liu P., Derendorf H.  “Microdialysis in Peripheral Tissues.”  Advance Drug Delivery Review, 45:189-216 (2000).