NICHOLAS BODOR, PH.D., D.SC.

GRADUATE RESEARCH PROFESSOR
DEPARTMENT OF PHARMACEUTICS
EXECUTIVE DIRECTOR, CENTER FOR DRUG DISCOVERY

V RAVI CHANDRAN, PH.D.
PROFESSOR IN DRUG DESIGN AND TARGETING
DEPARTMENT OF PHARMACEUTICS
CENTER FOR DRUG DISCOVERY

Phone:  352-392-3417        Fax:  352-392-8589        Email:  bodor@cop.ufl.edu

RESEARCH INTERESTS

  • Theoretical and mechanistic organic chemistry, medicinal chemistry, enzymology, drug design, drug delivery and drug development
  • Application of organic and physical chemistry to the design of safer drugs and chemicals
  • Development of a general, comprehensive program using a computerized, expert system to design safe, active soft drugs
  • Novel, soft drugs: corticosteroids, b-blockers, anticholinergics, etc.
  • Organ (brain, eye, lung) targeting of drugs by chemical/enzymatic principles
    •  AREAS OF TECHNICAL EXPERTISE
  • Development of retrometabolic drug design concepts, which combine "chemical drug targeting systems" (CDS), and "soft drugs" (SD), the two extremes of the retrometabolic design loop
  • Development of the first successful brain targeting-delivery of neuropeptides, which combines the redox targetor with strategically selected amino acid "spacers" and large lipophilic surrounding (cholesterol) called "molecular packaging" and sequential metabolism"
  • Computer-assisted drug design
    • CONSULTING EXPERTISE
  • Consultant in the field of drug design, delivery and development
  • Review of research, development and animal and human testing of drug candidates
    • SELECTED PUBLICATIONS
    1. Bodor N., Buchwald P.  “Barriers to Remember:  Brain-Targeting Chemical Delivery Systems and Alzheimer’s Disease.”  Drug Discovery Today, 7(14):766-774 (2002).
    2. Bodor N., Farag H., Polgar P.  “A Tryptamine Analog with High Affinity to the Heart Tissues in a Potential Antiarrhythmic Agent.”  Journal of Pharmacy and Pharmacology, 53(6):889-894 (2001).
    3. Bodor N., Buchwald P.  “Soft Drug Design:  General Principles and Recent Applications.” Medicinal Research Reviews, 20:58-101 (2000).
    4. Bodor N., Kaminski J. “Chemical Approaches to Drug Delivery.”  Encyclopedia of Controlled Drug Delivery, 1:285-298 (1999).
    5. Buchwald P., Bodor N.  “Quantitative Structure-Metabolism Relationships: Steric and Other Effects in the Enzymatic Hydrolysis of Non-Congener Carboxylic Esters.”  Journal of Medicinal Chemistry, 42:5160-5168 (1999).