RESEARCH INTERESTS

Drug and xenobiotic biotransformation

Mechanistic toxicology

Intestinal bioavailability of xenobiotics

Cytochrome P450-dependent biotransformation

Glutathione conjugation

Sulfonation

Epoxide metabolism

Enzymology

Analytical chemistry

Protein Chemistry

In vivo/in vitro correlations

Use of fish models for intestinal bioavailability studies

Use of rat models for drug metabolism in vivo and in vitro

Drug metabolism

Animal models

Toxicology related to metabolism

1. van den Hurk P., Kubiczak G.A., Lehmler H.J., James M.O.  “Hydroxylated Polychlorinated Biphenyls as Inhibitors of the Sulfation and Glucuronidation of 3-hydroxy- benzo[a]pyrene.” Environ. Health Perspect., 110:343-348 (2002).
2. James M.O., Tong Z, Rowland-Faux L., Venugopal C.S., Kleinow K.M.  “Intestinal Bioavailability and Biotransformation of 3-hydroxybenzo(a)pyrene in an Isolated Perfused Preparation from Channel Catfish, Ictalurus Punctatus.”  Drug Metabolism and Disposition, 29:721-728 (2001).
3. Li C.L.J., James M.O.  “Oral Bioavailability and Pharmacokinetics of Elimination 9-hydroxybenzo(a)pyrene and its Glucoside and Sulfate Conjugates After Administration to the American Lobster, Homarus Americanus.”  Toxicol. Sci., 57:75-86 (2000).
4. James M.O., Yan Z., Cornett R., Jayanti V.M., Henderson G.N., Davydova N., Katovich M.J., Pollock B., Stacpoole P.W.  “Pharmacokinetics and Metabolism of [14C]-dichloroacetic Acid in the Male Sprague-Dawley rat:  Identification of Glycine Conjugates, Including Hippurate, as Urinary Metabolites of Dichloroacetate.”  Drug Metab. Disp.,  26:1134-1143 (1998).
5. James M.O., Altman A.H., Morris K., Kleinow K.M., Tong, Z.  “Dietary Modulation of Phase 1 and Phase 2 Activities with Benzo(a)pyrene and Related Compounds in Intestine but Not Liver of the Channel Catfish, Ictalurus Punctatus.”  Drug Metab. Disp., 25:346-354 (1997).