University of Florida

College of Pharmacy
Department of Pharmacodynamics

College of Pharmacy
Department of Pharmacodynamics

My lab specializes in cellular neurophysiology and optical imaging. In a large sense, our work contributes towards development of a thorough mechanistic understanding of how excitability is regulated, and information is processed, at the synaptic level in the mammalian CNS. We also attempt to use such information to develop a better understanding of how the brain fails to work in a number of abnormal or diseased states (from geriatric memory dysfunction, to epilepsy, to drug abuse). We believe that these steps will be essential if science is to eventually enable development of therapeutic interventions for such disorders that are equal to our ambitions.

At present we have two specific areas of research focus. The first is on endocannabinoid mediated signaling in rodent hippocampus and dentate gyrus. The second is on the role of ambient GABA and high affinity GABA receptors in the modulation of synaptic transmission and network excitability.

In addition, we are also very invested in technology development and application in neurobiology. Consistent with that interest, we have recently completed construction of a 2-photon based laser scanning epifluorescence microscope that is well integrated into a system capable of high end conventional cellular neurophysiology. We are currently working with this technology in anticipation of testing specific hypotheses about both cannabinoid dependent and GABAergic signaling that would not otherwise be possible.

We are often looking for highly motivated students and postdocs with a strong technical background and a sincere interest in the work. Please send inquiries about available positions directly to frazier@cop.ufl.edu.