JEFFREY HUGHES, PH.D.

ASSOCIATE PROFESSOR

DEPARTMENT OF PHARMACEUTICS

RESEARCH INTERESTS

1. Drug delivery

2. Gene therapy

3. Liposomes

4. Membrane fusion

5. Nucelic acid stability

6. Transgene expression in the brain

7. Targeted drug delivery

8. Macromolecule formulation

9. Macrophase biology

AREAS OF TECHNICAL EXPERTISE

1. Liposome formulation
2. Delivery of nucleic acids
3. Tissue caltune
4. Diposition of macromolecules
5. Membrane fusion via surfactants
6. Mycobacteria biology

CONSULTING EXPERTISE

1. Cygene

Telephone (352) 846-2725
Fax (352) 392-4447
E-mail hughes@cop.ufl.edu

SAMPLE PUBLICATIONS

1. Wang S, Bui V, Hughes JA, King MA, Meyer EM, Adeno-associated virus mediated gene transfer into primary rat brain neuronal and glial cultures: enhancement with the pH-sensitive surfactant dodecyl 2-(1'-imidazolyl) propionate. Neurochemistry International 2000;4:1-6.
2. Poxon SW and Hughes JA, The effect of lyophilization on plasmid DNA activity. Pharm Dev Tech 2000;5:115-122.
3. Poxon SW and Hughes JA Characterization of endotoxin and cationic liposome interaction Pharm Dev Technol 1999;4:135-143.
4. Poxon, S.W. and Hughes JA Foam fractionation as a method to separate endotoxin from recombinant biotechnology products J Pharm Sci Technol 1999;53:23-26.
5. Ajmani P, Hughes JA 3-[N-(N,n’dimethylaminoethane)-carbamoyl-cholesterol] (DC-CHOL)-mediated gene delivery to primary rat neurons "Characterization and mechanisms". Neurochemical Research 1999;24:699-703.