NICHOLAS BODOR, PH.D., D.SC.

Graduate Research Professor, Ph.D., D.Sc., D.Sc. (hon)

Executive Director, Center for Drug Discovery

V. Ravi Chandran PhD Professor in Drug Design and Targeting,


Department of Pharmaceutics

RESEARCH INTERESTS

  1. Theoretical and mechanistic organic chemistry, medicinal chemistry, enzymology, drug design, drug delivery and drug development.
  2. Application of organic and physical chemistry to the design of safer drugs and chemicals.
  3. Development of a general, comprehensive program using a computerized, expert system to design safe, active soft drugs.

AREAS OF TECHNICAL EXPERTISE

  1. Development of retrometabolic drug design concepts, which combine "chemical drug targeting systems" (CDS) and "soft drugs" (SD), the two extremes of the retrometabolic design loop.
  2. Development of the first successful brain targeting-delivery of neuropeptides, which combines the redox targetor with strategically selected amino acid "spacers" and large lipophilic surrounding (cholesterol) called "molecular packaging" and sequential metabolism".
  3. Computer-assisted drug design.

CONSULTING EXPERTISE

  1. Consultant in the field of drug design, delivery and development.
  2. Review of research, development and animal and human testing of drug candidates.

Telephone (352) 392-3417
Fax (352) 392-8589
E-mail bodor@cop.ufl.edu

SAMPLE PUBLICATIONS

  1. Bodor, N. Design of biologically safer chemicals. Chemtech, 1995, 25 (10), 22-32.
  2. Bodor, N. Retrometabolic drug design concepts in ophthalmic target-specific drug delivery. Adv. Drug Deliv. Rev., 1995, 16, 21-38.
  3. Bodor, N.; Buchwald, P. Drug targeting via retrometabolic approaches. Pharmacol. Ther., 1997, 76, 1-27.
  4. Bodor, N.; Buchwald, P. All in the mind. Chem. Br., 1998, 34 (1), 36-40.
  5. Bodor, N.; Buchwald, P. Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems. Adv. Drug Deliv. Rev., 1999, 36, 229-254.
  6. Chen, P.; Bodor, N.; Wu, W.-M.; Prokai, L. Strategies to target kyotorphin analogues to the brain. J. Med. Chem., 1998, 41, 3773-3781.
  7. Buchwald, P.; Bodor, N. Quantitative structure-metabolism relationships: steric and nonsteric effects in the enzymatic hydrolysis of noncongener carboxylic esters. J. Med. Chem., 1999, 42, 5160-5168.

Last modified 06/12/01