Publications
Liu, Y.; Kern, J. T.; Walker, J. R.; Johnson, J. A.; Schultz, P. G.; Luesch, H. “A Genomic Screen for Activators of the Antioxidant Response Element” Proc. Natl. Acad. Sci. USA 2007, 104, 5205–5210.
Matthew, S.; Ross, C.; Rocca, J. R.; Paul, V. J.; Luesch, H. “Lyngbyastatin 4, a Dolastatin 13 Analogue with Elastase and Chymotrypsin Inhibitory Activity from the Marine Cyanobacterium Lyngbya confervoides ” J. Nat. Prod. 2007, 70, 124–127.
Luesch, H. “Towards High-Throughput Characterization of Small Molecule Mechanisms of Action” Mol. BioSyst. 2006, 2, 609–620.
Luesch, H.; Chanda, S. K.; Raya, R. M.; DeJesus, P. D.; Orth, A. P.; Walker, J. R.; Izpisúa Belmonte, J. C.; Schultz, P. G. “A Functional Genomics Approach to the Mode of Action of Apratoxin A” Nat. Chem. Biol. 2006 , 2 , 158–167.
Luesch, H.; Wu, T. Y. H.; Ren, P.; Gray, N. S.; Schultz, P. G.; Supek, F. “A Genome-Wide Overexpression Screen in Yeast for Small-Molecule Target Identification” Chem. Biol. 2005 , 12 , 55–63.
Williams, P. G.; Luesch, H.; Yoshida, W. Y.; Moore, R. E.; Paul, V. J. “Continuing Studies on the Cyanobacterium Lyngbya sp.: Isolation and Structure Determination of 15-Norlyngbyapeptin A and Lyngbyabellin D” J. Nat. Prod. 2003 , 66 , 595–598.
Mooberry, S. L.; Leal, R. M.; Tinley, T. L.; Luesch, H.; Moore, R. E.; Corbett, T. H. “The Molecular Pharmacology of Symplostatin 1: A New Antimitotic Dolastatin 10 Analog” Int. J. Cancer 2003 , 104 , 512–521.
Luesch, H.; Hoffmann, D.; Hevel, J. M.; Becker, J. E.; Golakoti, T.; Moore, R. E. “Biosynthesis of 4-Methylproline in Cyanobacteria: Cloning of nosE and nosF Genes and Biochemical Characterization of the Encoded Dehydrogenase and Reductase Activities” J. Org. Chem. 2003 , 68 , 83–91.
Luesch, H.; Yoshida, W. Y.; Harrigan, G. G.; Doom, J. P.; Moore, R. E.; Paul, V. J. “Lyngbyaloside B, a New Glycoside Macrolide from a Palauan Marine Cyanobacterium, Lyngbya sp.” J. Nat. Prod. 2002 , 65 , 1945–1948.
Luesch, H.; Harrigan, G. G.; Goetz, G.; Horgen, F. D. “The Cyanobacterial Origin of Potent Anticancer Agents Originally Isolated from Sea Hares” Curr. Med. Chem. 2002 , 9 , 1791–1806.
Luesch, H.; Yoshida, W. Y.; Moore, R. E.; Paul, V. J. “Structurally Diverse New Alkaloids from Palauan Collections of the Apratoxin-Producing Marine Cyanobacterium Lyngbya sp.” Tetrahedron 2002 , 58 , 7959–7966.
Luesch, H.; Williams, P. G.; Yoshida, W. Y.; Moore, R. E.; Paul, V. J. “Ulongamides A-F, New β-Amino Acid Containing Cyclodepsipeptides from Palauan Collections of the Marine Cyanobacterium Lyngbya sp.” J. Nat. Prod. 2002 , 65 , 996–1000.
Luesch, H.; Yoshida, W. Y.; Moore, R. E.; Paul, V. J. “New Apratoxins of Marine Cyanobacterial Origin from Guam and Palau” Bioorg. Med. Chem. 2002 , 10 , 1973–1978.
Luesch, H. “The Search for New Antitumor Drugs from Marine Cyanobacteria” Abstract from the 26 th Annual Albert L. Tester Symposium; Pacific Science 2002 , 56 , 83–100.
Luesch, H.; Yoshida, W. Y.; Moore, R. E.; Paul, V. J.; Mooberry, S. L.; Corbett, T. H. “Symplostatin 3, a New Dolastatin 10 Analogue from the Marine Cyanobacterium Symploca sp. VP452” J. Nat. Prod. 2002 , 65 , 16–20.
Harrigan, G. G.; Goetz, G. H.; Luesch, H.; Yang, S.; Likos, J. “Dysideaprolines A–F and Barbaleucamides A–B, Novel Polychlorinated Compounds from a Dysidea Species” J. Nat. Prod. 2001, 64, 1133–1138.
Luesch, H.; Moore, R. E.; Paul, V. J.; Mooberry, S. L.; Corbett, T. H. “Isolation of Dolastatin 10 from the Marine Cyanobacterium Symploca Species VP642 and Total Stereochemistry and Biological Evaluation of its Analogue Symplostatin 1” J. Nat. Prod. 2001, 64 ,907–910.
Luesch, H.; Yoshida, W. Y.; Moore, R. E.; Paul, V. J.; Corbett, T. H. “Total Structure Determination of Apratoxin A, a Potent Novel Cytotoxin from the Marine Cyanobacterium Lyngbya majuscula ” J. Am. Chem. Soc. 2001 , 123 , 5418–5423.
Luesch, H.; Pangilinan, R.; Yoshida, W. Y.; Moore, R. E.; Paul, V. J. “Pitipeptolides A and B, New Cyclodepsipeptides from the Marine Cyanobacterium Lyngbya majuscula ” J. Nat. Prod. 2001 , 64, 304–307.
Lüsch, H.; Uzar, H. C. “New access to the synthetic building block L-aspartic acid β-semialdehyde via Grignard reaction” Tetrahedron: Asymmetry 2000 , 11 , 4965–4973.
Brinkmann, T.; Gilg, A.; Hamm, A.; Lüsch, H.; Morbach, G.; Uzar, H.C. “Reaction of aspartic acid derivatives with Grignard reagents—synthesis of γ,γ-disubstituted α- and β-amino-butyrolactones” Tetrahedron: Asymmetry 2000 , 11 , 3827–3836.
Harrigan, G. G.; Luesch, H.; Moore, R. E.; Paul, V. J. “The Anticancer Dolastatins as Cyanobacterial Metabolites” In Biodiversity: New Leads for the Pharmaceutical and Agrochemical Industries ; Wrigley, S. K., Hayes, M. A., Thomas, R., Chrystal, E. J. T., Nicholson, N., Eds.; RSC Press: UK, 2000 ; pp 126–139.
Luesch, H.; Yoshida, W. Y.; Moore, R. E.; Paul, V. J. “Isolation and Structure of the Cytotoxin Lyngbyabellin B and Absolute Configuration of Lyngbyapeptin A from the Marine Cyanobacterium Lyngbya majuscula ” J. Nat. Prod. 2000 , 63 , 1437–1439.
Luesch, H.; Yoshida, W. Y.; Moore, R. E.; Paul, V. J. “Apramides A–G, Novel Lipopeptides from the Marine Cyanobacterium Lyngbya majuscula ” J. Nat. Prod. 2000 , 63 , 1106–1112.
Luesch, H.; Yoshida, W. Y.; Moore, R. E.; Paul, V. J.; Mooberry, S. L. “Isolation, Structure Determination, and Biological Activity of Lyngbyabellin A from the Marine Cyanobacterium Lyngbya majuscula ” J. Nat. Prod. 2000 , 63 , 611–615.
Luesch, H.; Yoshida, W. Y.; Moore, R. E.; Paul, V. J. “Lyngbyastatin 2 and Norlyngbyastatin 2, Analogues of Dolastatin G and Nordolastatin G from the Marine Cyanobacterium Lyngbya majuscula ” J. Nat. Prod . 1999 , 62 , 1702–1706.
Harrigan, G. G.; Luesch, H.; Yoshida, W. Y.; Moore, R. E.; Nagle, D. G.; Paul, V. J. “Symplostatin 2: A Dolastatin 13 Analogue from the Marine Cyanobacterium Symploca hydnoides ” J. Nat. Prod. 1999 , 62 , 655–658.
Harrigan, G. G.; Luesch, H.; Yoshida, W. Y.; Moore, R. E.; Nagle, D. G.; Biggs, J.; Park, P. U.; Paul, V. J. “Tumonoic Acids, Novel Metabolites from a Cyanobacterial Assemblage of Lyngbya majuscula and Schizothrix calcicola ” J. Nat. Prod. 1999 , 62 , 464–467.
Harrigan, G. G.; Luesch, H.; Yoshida, W. Y.; Moore, R. E.; Nagle, D. G.; Paul, V. J.; Mooberry, S. L.; Corbett, T. H.; Valeriote, F. A.“Symplostatin 1: A Dolastatin 10 Analogue from the Marine Cyanobacterium Symploca hydnoides ” J. Nat. Prod. 1998 , 61 , 1075–1077.
