Kenneth Sloan Ph.D.
Professor
University of Missouri, 1969
Research Interests
Effect of nucleophilicity and nucleofugicity on SN2 reactions. The diffusion of heterocycles, anti-cancer, antiviral, steroidal and nonsteroidal anti-inflammatory agents through membranes and specially skin. Prodrug and soft drug approaches to improved analgetics and steroids.
Sample Publications
1. H.D. Beall, R.J. Prankerd, L.J. Todaro, and K.B. Sloan, "Structure of 3-Acetyl-5-Fluoroucil: Implications for its rearrangements during hydrolysis and upon heating," Pharm. Res., 10, 905-912 (1993).
2. H.D. Beall, K.B. Sloan, "Transdermal Delivery of 5-Fluorouracil (5FU) by Alkylcarbonyl-5FU Prodrugs: Int. J. Pharm., 129, 203-210 (1996).
3. H.E. Taylor, K.B. Sloan, "1-Alkylcarbonyloxymethyl Prodrugs of 5-Fluorouracil (5FU): Synthesis, Physicochemical Properties and Topical Delivery of 5FU," J. Pharm. Sci., 87, 15-20. (1998).
4. J.J. Getz, R.J. Prankerd, and K.B. Sloan, "Mechanism of Hydrolysis of Benzamidomethyl Derivatives of Phenols and its Implications for Prodrug Design," J. Org. Chem., 57, 1702-1706 (1992).
