Education
- Ph.D. in Clinical Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy
- Pharm.D., Mercer University School of Pharmacy
- B.S. in Biology, Oglethorpe University
Biographical Sketch
Frye is a Associate Professor and Chair for the Department of Pharmacotherapy and Translational Research College of Pharmacy and Associate Director, University of Florida Center for Pharmacogenomics. He received a B.S. in Biology from Oglethorpe University, a Pharm.D. from Mercer University School of Pharmacy, and a Ph.D. in Clinical Pharmaceutical Sciences from the University of Pittsburgh School of Pharmacy. After completing graduate work, he remained on faculty at the University of Pittsburgh from 1995 until 2003, being promoted to Associate Professor with tenure in 2002. He joined the faculty at the University of Florida in July 2003.
Research Interests
- Frye’s clinical research program has focused on the identification and characterization of factors that contribute to interindividual variability in drug response. Current focus is on genetic and non genetic (e.g., age, disease) factors that cause variability in drug metabolism, which can be assessed with in vivo probes that can measure the activity of specific drug-metabolizing enzymes in individual subjects. Frye has received funding for his research from the Pharmaceutical Industry and the National Institutes of Health.
Publications
Mohamed ME, Frye RF, Effects of Herbal Supplements on Drug Glucuronidation, Review of Clinical, Animal, and in Vitro Studies, Planta Med, 2010 Nov 3.
Gilbertson R, Frye RF, Nixon SJ, Nicotine as Factor in Stress Responsiveness Among Detoxified Alcoholics, Alcohol Alcohol, 2010 Nov 2.
Navare HA, Frye RF, Cooper-DeHoff RM, et al, Atenolol exposure and risk for development of adverse metabolic effects: a pilot study, Pharmacotherapy, 2010 Sep;30(9):872-878.
Mohamed ME, Tseng T, Frye RF, Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity, Xenobiotica, 2010 Oct;40(10):663-669.
Stanton ML, Joy MS, Frye RF, Validation and application of a liquid chromatography-tandem mass spectrometric method for quantification of the drug transport probe fexofenadine in human plasma using 96-well filter plates, J Chromatogr B Analyt Technol Biomed Life Sci, 2010 Feb 1;878(3-4):497-501.
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